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Exam 20: Genetic Analysis of Quantitative Traits

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Question 31

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In the same population of patients you examined for sickle cell allele frequencies, you now want to test whether the disease symptoms are related to blood type. Since blood type is a codominant trait and the alleles are easily identifiable by the phenotype (blood type) of the individuals, which method is most helpful for identifying blood type allele frequency?

A) square root method
B) chi- square test
C) genotype proportion method
D) allele- counting method
E) binomial expansion

F) C) and D)
G) A) and C)

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Question 32

Multiple Choice

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A researcher is studying a newly discovered gene that causes increased body weight in domesticated chickens. In a mainland population, the frequency of the A₁ allele is 0.2, for this gene with two alleles. If 100 of these mainland chicken are transported on a ship to an isolated island with a population of 200 A₁A₁ chickens, 400 A₁A₂ chickens, and 400 A₂A₂ chickens, what would the frequency of the A₁ allele in the admixed population?

A) 0.764
B) 0.618
C) 0.745
D) 0.236
E) 0.382

F) C) and D)
G) C) and E)

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Question 33

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When looking at the MN blood group with two alleles, how many degrees of freedom will be used to compare observed versus expected results?

During a University of Nevada, Reno blood donation campaign, the frequencies of alleles determining the ABO blood groups were 0.70 for i, 0.2 for I^A and 0.1 for I^B. Assuming random mating, what is the expected frequency of blood type B?

Given the following pedigree, what is the coefficient of inbreeding for individual G? Use Key Analytic Tool pedigree in Chapter 20, page 402 from SGSM

If the frequency of PKU, an autosomal recessive disease, is 1% in males, what is the frequency of females with PKU? (You may assume that the population is in Hardy- Weinberg equilibrium.)

Explain why rare recessive alleles are more likely to produce a recessive phenotype as a result of inbreeding.

Which of the following is an example of a postzygotic mechanism for reproductive isolation?

If an X- linked recessive trait has a frequency of 5% in males, what percentage of females are carriers? (Assume that the population is in Hardy- Weinberg equilibrium.)

You want to calculate the frequency of the allele causing sickle cell disease in your patients, and you know the genotypes of every individual. Assuming the population is not in Hardy- Weinberg equilibrium due to population substructure, which method can be used to calculate allele frequency?

In a theoretical population where f (A₁) = 0.95 and f (A₂) = 0.05, µ = 1 × 10^{- 6}, and v = 1 × 10^{- 7}, what is Oq?

The incidence of phenylketonuria (PKU) , an autosomal recessive genetic disorder, is approximately 1 in 4,500 in Ireland. Assuming Hardy- Weinberg equilibrium, what is the probability that a phenotypically normal Irish female, with no family history, and a phenotypically normal Irish male, with an affected sister, will have a child with PKU?

The process by which an original species is transformed into a new species over an extended period of time that spans many generations is known as_________ .

Phenylketonuria (PKU) is extremely common in Ireland, affecting approximately 1 in 4500 live births. Assuming that the population is in Hardy- Weinberg equilibrium, what is the frequency of PKU carriers?