A) adenovirus-mediated
B) retrovirus-mediated
C) liposome-mediated
D) A and B
F) None of the above
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A) activates the p21 gene which encodes a CDK inhibitor, thereby causing G1 arrest.
B) promotes apoptosis.
C) phosphorylates the retinoblastoma protein (pRB) , thereby blocking the cell cycle.
D) is targeted for degradation by the proteasome.
F) A) and D)
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If the gene is a proto-oncogene then its...View Answer
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A) No; all the body cells of the patient are dividing uncontrollably.
B) Yes; surgery could remove all the patient's cells with defective cell-cycle regulation.
C) No; cancer cells are no longer localized in one spot in the patient.
D) Yes; if the patient's tumor is benign.
F) None of the above
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To diagram the hypothesized action of a ...View Answer
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Ornithine transcarbamylase (OTC) deficie...View Answer
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A) has only been tested in cell culture and animal models
B) is experimental and has never achieved any clinical success.
C) is experimental and has achieved only very limited clinical success.
D) is routine and has been used successfully to treat many diseases.
F) A) and B)
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The two main mechanisms for transformati...View Answer
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A) A gene associated with tumor formation when its product does not function.
B) A gene associated with tumor formation when it is inappropriately activated.
C) A gene that inhibits cell growth when its product functions normally.
D) A gene that codes for a transcription factor involved in tumor formation.
F) B) and D)
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Inappropriate activation of proto-oncoge...View Answer
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C-myc is referred to as a central "oncog...View Answer
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A) remove all viral coat proteins.
B) remove all viral genes, replacing them with the human genes to be delivered.
C) remove select viral genes and replace them with the human genes to be delivered.
D) remove the viral genome and coat proteins and replace them with plasmids carrying the human genes to be delivered.
F) B) and C)
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A) immortalization
B) transformation
C) metastasis
D) carcinogenesis
F) B) and D)
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Chronic myelogenous leukemia (CML) is a ...View Answer
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A) dephosphorylating ABL substrates
B) blocking the active site of the ABL tyrosine kinase so that ATP cannot bind
C) binding to BCR in a way that inhibits its ability to activate ABL
D) degrading the ABL-BCR fusion protein
F) All of the above
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Deletions of both alleles of p53 or miss...View Answer
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A) they can infect both dividing and nondividing cells.
B) they have a limited insert size.
C) they have generate only a mild immune response
D) they stably integrate into host chromosomes
F) A) and C)
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A) monogenic loss-of-function metabolic diseases
B) multigenic behavioral diseases
C) viral diseases
D) immunodeficiencies
F) B) and C)
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A) at least four to eight genetic changes over the course of years
B) mutation of the cancer gene
C) at least 20 genetic changes over the course of years
D) at least four to eight genetic changes over the course of days
F) None of the above
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In vivo and ex vivo somatic cell gene th...View Answer
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