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Destruction of lymphocytes with self specificity is called


A) clonal deletion.
B) proliferation.
C) clonal selection.
D) differentiation.
E) hypersensitivity.

F) A) and E)
G) C) and D)

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The immunoglobulin/s found on the surface of B cells is/are


A) IgM only.
B) IgG only.
C) IgD only.
D) IgM and IgD.
E) IgD and IgE.

F) B) and C)
G) None of the above

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An example of natural active immunity would be


A) chickenpox infection followed by lifelong immunity.
B) chickenpox vaccine which triggers extended immunity to chickenpox.
C) giving a person immune serum globulins to chickenpox virus after exposure to the disease.
D) a fetus acquiring maternal IgG to the chickenpox virus across the placenta.
E) None of the choices is correct.

F) A) and D)
G) None of the above

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Human B lymphocytes mature in an intestinal region called the bursa.

A) True
B) False

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Which process involves antibodies cross-linking cells or particles into large aggregates?


A) neutralization
B) opsonization
C) complement fixation
D) agglutination
E) anamnestic response

F) B) and C)
G) All of the above

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After secreting antibodies during an immune response,plasma cells then differentiate into memory cells.

A) True
B) False

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. Marie is a 57-year-old female who is on your general medical-surgical unit with a bladder infection. Two weeks ago, she was having slight burning upon urination. She self-treated with an increased intake of cranberry juice, but did not see any improvement. In fact, her symptoms got worse. Last week, she developed generalized abdominal pain and a mid-grade fever. She did not come into the hospital until the pain was unbearable and she had a fever of 104F. She was admitted to your unit and started on multiple IV antibiotics. The doctors say that she could be developing a kidney infection. -What previous lines of defense have been breached in Marie's case?


A) Only the first line of defense has been breached.Her second line of defense is fighting off this infection.
B) No lines of defense have yet been breached.Her intact barrier system is keeping her kidneys from becoming infected.
C) The second line of defense has been breached.Her lymphocytes are now being challenged by this infection.
D) There are no lines of defense for this sort of infection.

E) C) and D)
F) B) and C)

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The structural and functional differences that distinguish immunoglobulin isotypes are due to variations associated with their Fc fragments.

A) True
B) False

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. Marie is a 57-year-old female who is on your general medical-surgical unit with a bladder infection. Two weeks ago, she was having slight burning upon urination. She self-treated with an increased intake of cranberry juice, but did not see any improvement. In fact, her symptoms got worse. Last week, she developed generalized abdominal pain and a mid-grade fever. She did not come into the hospital until the pain was unbearable and she had a fever of 104F. She was admitted to your unit and started on multiple IV antibiotics. The doctors say that she could be developing a kidney infection. -Which part of the IgG molecule will bind with the


A) Fab
B) Fc
C) heavy chain
D) light chain
E) coli antigen in Marie's body?

F) B) and E)
G) C) and D)

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Helper T cells


A) secrete antibodies.
B) function in allergic reactions.
C) directly destroy target cells.
D) suppress immune reactions.
E) activate B cells and other T cells.

F) D) and E)
G) A) and B)

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Lymphocytes


A) possess MHC antigens for recognizing self.
B) have membrane receptors that recognize foreign antigens.
C) gain tolerance to self by destruction of lymphocytes that could react against self.
D) develop into clones of B and T cells with extreme variations of specificity.
E) All of the choices are correct.

F) All of the above
G) B) and E)

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An activated TH cell produces ___ which is a growth factor for T helper cells and cytotoxic T cells.


A) interleukin-1
B) interleukin-2
C) interleukin-12
D) antiserum
E) complement

F) C) and E)
G) A) and D)

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An example of artificial passive immunity would be


A) chickenpox infection followed by lifelong immunity.
B) chickenpox vaccine which triggers extended immunity to chickenpox.
C) giving a person immune serum globulins to chickenpox virus after exposure to the disease.
D) a fetus acquiring maternal IgG to the chickenpox virus across the placenta.
E) None of the choices is correct.

F) All of the above
G) A) and B)

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Which process involves antibodies coating microorganisms in order to facilitate phagocytosis?


A) neutralization
B) opsonization
C) complement fixation
D) agglutination
E) anamnestic response

F) A) and B)
G) A) and C)

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Live,attenuated vaccines


A) include the Sabin polio vaccine.
B) include the measles,mumps,rubella vaccine (MMR) .
C) contain viable microbes that can multiply in the person.
D) require smaller doses and fewer boosters compared to inactivated vaccines.
E) All of the choices are correct.

F) None of the above
G) D) and E)

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The most significant cells in graft rejection are


A) helper T cells.
B) suppressor T cells.
C) cytotoxic T cells.
D) delayed hypersensitivity T cells.
E) natural killer (NK) cells.

F) A) and D)
G) C) and D)

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All of the following are characteristics of IgM except


A) has 10 antigen binding sites.
B) contains a central J chain.
C) is the first class synthesized by a plasma cell.
D) can serve as a B-cell receptor.
E) is a dimer.

F) A) and C)
G) A) and E)

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MHC molecules are found on each of the following cells except


A) leukocytes.
B) eosinophils.
C) epithelial cells.
D) red blood cells.
E) islet of Langerhans cells.

F) None of the above
G) C) and D)

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. The Smith family has brought their 2-week-old son into your family practice office for his 2-week checkup. He is their first son, and they are very anxious. They have already expressed multiple concerns to you concerning sleep, feeding, and crying, but their concerns have been about things that are typical for a newborn. You try your best to calm their fears, and they are receptive for the most part. However, when it comes time to discuss vaccination with them, they refuse to vaccinate their son because they report they have heard vaccines can cause autism in children. -Which of the following statements is not true concerning vaccines?


A) They consist of killed or inactivated cells.
B) They consist of live but weakened microbes.
C) It is possible to be allergic to vaccine preparations.
D) Autism only happens in rare instances of vaccination.

E) B) and C)
F) All of the above

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Antitoxins


A) contain modified bacterial exotoxin molecules.
B) are always genetically engineered.
C) contain select antigenic components of a pathogen rather than whole cells or viruses.
D) confer passive immunity.
E) utilize DNA strands that will produce the antigen.

F) B) and E)
G) A) and B)

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